{"id":21949,"date":"2024-04-22T10:27:51","date_gmt":"2024-04-22T10:27:51","guid":{"rendered":"https:\/\/kaeltia.com\/?p=21949"},"modified":"2024-05-08T13:58:37","modified_gmt":"2024-05-08T11:58:37","slug":"hazard-coformulants-kaeltia","status":"publish","type":"post","link":"https:\/\/kaeltia.com\/en\/hazard-coformulants-kaeltia\/","title":{"rendered":"Hazard Coformulants Assessment (Part 2)"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_77 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a0958c7209da\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"ez-toc-cssicon\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a0958c7209da\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/kaeltia.com\/en\/hazard-coformulants-kaeltia\/#ITEM_3_Strategy_to_identify_combined_effects_and_level_of_data\" >ITEM 3_Strategy to identify combined effects and level of data<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/kaeltia.com\/en\/hazard-coformulants-kaeltia\/#ITEM_4_Specific_co-formulants\" >ITEM 4_Specific co-formulants<\/a><\/li><\/ul><\/nav><\/div>\n<p>&nbsp;<\/p>\n<h5><span class=\"ez-toc-section\" id=\"ITEM_3_Strategy_to_identify_combined_effects_and_level_of_data\"><\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text001\">ITEM 3_Strategy to identify combined effects and level of data<\/span><span class=\"ez-toc-section-end\"><\/span><\/h5>\n<p>&nbsp;<\/p>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">There<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">non-exhaustive<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">list<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">existing<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">predictive<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">tools<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">that<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">take<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">into<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">account<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">potential<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">interactions<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">between <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">substances<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">as<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">TEST,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">QSAR<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">or<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">BPR<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">documents.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">The<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proposed<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">solutions<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">are<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">follow<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">guidance<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">documents <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">assess<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">combined<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">exposure<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">for<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">ecotoxicology<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">toxicology.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Also,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">CLP<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">calculation<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">can<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">be<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">used<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">conduct <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">additive<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">assessment.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">It<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proposed<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">collect<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">data<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">on<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">synergistic<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">effects<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">by<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">conducting<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">systematic<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">literature <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">search.<\/span><\/div>\n<div><\/div>\n<h5 class=\"p2-876cecc34c2-div\"><span class=\"ez-toc-section\" id=\"ITEM_4_Specific_co-formulants\"><\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text001\">ITEM 4_Specific co-formulants<\/span><span class=\"ez-toc-section-end\"><\/span><\/h5>\n<div><\/div>\n<ul>\n<li class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a)<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Co-formulants that are approved\/no more approved\/not approved as pesticide a.s.<\/span><\/li>\n<\/ul>\n<div><\/div>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">If<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">co-formulant<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">has<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proven<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">pesticidal<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">activity<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">in<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PPP,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">it<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">should<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">be<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">declared<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">as<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a.s.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">And<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">composition <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of PPP should be reviewed by the physical chemical experts.<\/span><\/div>\n<div><\/div>\n<ul>\n<li class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">b)<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Co-formulants that are polymers in PPP<\/span><\/li>\n<\/ul>\n<div><\/div>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">In<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">principle,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">for<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">human<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">health,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">there<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">no<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">concerns<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">as<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">currently<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">they<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">are<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">exempt<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">from<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">REACH<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">registration. <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">For<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">environment,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">there<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">concerns<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">due<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">accumulation<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">plastic<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">in<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">nature.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">However,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">due<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">current <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">concerns<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">as<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text002\">s<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">tability,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">toxicologically<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">relevant<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">residual<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">monomers,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">lack<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">data<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">on<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">toxicity,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">information<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">on <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">identity,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">assessment<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">alternatives<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">so<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">several<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">solutions<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">have<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">been<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proposed.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">For<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">example,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">acceptable<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PPP <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">storage<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">stability<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">data<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">indicate<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">stability<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">polymer<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">co-formulants<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">specifications<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">co-formulant <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">should<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">be<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">requested<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">demonstrate<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">concentration<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">identity<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">unreacted<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">monomers<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">present<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">in<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">polymer co-formulant.<\/span><\/div>\n<div><\/div>\n<ul>\n<li class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">c)<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Co-formulants that are UVCBs<\/span><\/li>\n<\/ul>\n<div><\/div>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Due<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">exact<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">composition<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">often<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">unknown,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">it<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">difficult<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">generalize<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">their<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">risk<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">profiles<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">or<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">establish <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">standard<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">test<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">protocols<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">for<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">their<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">evaluation.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">The<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proposed<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">solutions<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">are<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">use<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">ECHA<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">definition<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">request the performance and composition specification.<\/span><\/div>\n<div><\/div>\n<ul>\n<li class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">d)<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Co-formulants that are PFAS<\/span><\/li>\n<\/ul>\n<div><\/div>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">There<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PFAS<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">restriction<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proposals<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">list<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PFAS<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">also<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">identified<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">as<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">active<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">substances.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">The<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">proposed <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">solutions<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">are<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">to<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">use<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">OECD<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">ECHA<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">definition<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">if<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">there<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">co-formulant<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">meeting<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">the<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PFAS <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">definition, to consider for the risk assessment for mammalian toxicity and ecotoxicity.<\/span><\/div>\n<div><\/div>\n<ul>\n<li class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">e)<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Co-formulants that are formaldehyde releasers<\/span><\/li>\n<\/ul>\n<div><\/div>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">Formaldehyde cannot be used as a co-formulant<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">with exceedance of 0.1% as an impurity in<\/span><\/div>\n<div class=\"p2-876cecc34c2-div\"><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PPP.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">However,<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">there<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">are<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">intentional<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">unintentional<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">release<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">formaldehyde<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">as<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">impurities<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">from<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">co-<\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">formulants<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">used<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">in<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">PPP.<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">There<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">is<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">a<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">list<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">of<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">formaldehyde<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">releasers<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">that<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">can<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">be<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">checked<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">and<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">should<\/span> <span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">be <\/span><span class=\"p2-876cecc34c2-span p2-876cecc34c2-text003\">considered for risk assessment (mammalian toxicity and ecotoxicity).<\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; ITEM 3_Strategy to identify combined effects and level of data &nbsp; There is a non-exhaustive list of existing predictive tools that take into account potential interactions between substances as TEST, QSAR or BPR documents. The proposed solutions are to follow the guidance documents to assess combined exposure for ecotoxicology and toxicology. Also, the CLP calculation can be used to conduct additive assessment. It is proposed to collect data on[&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":21972,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_wpscppro_custom_social_share_image":0,"_facebook_share_type":"","_twitter_share_type":"","_linkedin_share_type":"","_pinterest_share_type":"","_linkedin_share_type_page":"","_selected_social_profile":[]},"categories":[68],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/posts\/21949"}],"collection":[{"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/comments?post=21949"}],"version-history":[{"count":3,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/posts\/21949\/revisions"}],"predecessor-version":[{"id":21954,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/posts\/21949\/revisions\/21954"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/media\/21972"}],"wp:attachment":[{"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/media?parent=21949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/categories?post=21949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kaeltia.com\/en\/wp-json\/wp\/v2\/tags?post=21949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}